BIOL 568 (Winter)

Topics on the Human Genome



Instructor(s):
 
R. Slim (Coordinator)
MUHC-RI, Glen
(514) 934-1934 ext44550
rima.slim@muhc.mcgill.ca
& Staff
 
R. Mackay (Administrator) SAD (514) 398-4198 ross.mackay@mcgill.ca
       
Workload:
 
3 credits (3-0-6)
 
 
Prerequisite(s):
 
BIOL 202, BIOL 300, BIOL 370 or permission of instructor.
 
 
Content:
 

The course will cover genomic, molecular and cellular approaches to characterization of the human genome.

1. Genome wide association studies: design, linkage disequilibrium, genetic risk scores (3 hours).
2. Next generation sequencing methods: Applications to RNA, genomic DNA and cDNA including a workshop and work with you own real data (6 hours).
3. Transcriptional regulation, chromatin structure and methods to study them including a workshop and hands-on CHIP-seq data analysis (6 hours).
4. DNA Methylation and human diseases (3 hours)
5. Genetic mosaicism and de novo mutations in human diseases (3 hours)
6. Genetics of cancer ontogeny (4.5 hours)
7. General developmental genetics and use of pluripotent stem cells (3 hours)
8. Ethical, Legal, and Social Aspects of Human Genomics Research (4.5 hours)
       
Readings:
 
Selected journal articles.
 
 
Method:
 
3 hours lectures.
 
 
Evaluation:
 
Mid-term and final exam.      
McGill University values academic integrity. Therefore all students must understand the meaning and consequences of cheating, plagiarism and other academic offences under the Code of Student Conduct and Disciplinary Procedures (see http://www.mcgill.ca/integrity/ for more information).

Last update: March 5, 2018