BIOL 568 (Winter)

Topics on the Human Genome

R. Slim (Coordinator)
(514) 934-1934 ext44550
& Staff
R. Mackay (Administrator) SAD (514) 398-4198
3 credits (3-0-6)
BIOL 202, BIOL 300, BIOL 370 or permission of instructor.

The course covers recent advances in next generation sequencing and their applications to various fields in biology. The course also covers various examples of inherited and acquired human diseases, approaches to study and modeling them, and ethical implications related to the use of data derived from human subjects.

1. Genome wide association studies: design, linkage disequilibrium, genetic risk scores (3 hours).
2. Next generation sequencing methods: Applications to RNA, genomic DNA and cDNA including a workshop and work with you own real data (6 hours).
3. Transcriptional regulation, chromatin structure and methods to study them including a workshop and hands-on CHIP-seq data analysis (6 hours).
4. DNA Methylation and human diseases (3 hours)
5. Genetic mosaicism and de novo mutations in human diseases (3 hours)
6. Genetics of cancer ontogeny (4.5 hours)
7. General developmental genetics and use of pluripotent stem cells (3 hours)
8. Ethical, Legal, and Social Aspects of Human Genomics Research (4.5 hours)
Selected journal articles.
Two 1.5 hour lectures per week.
Mid-term, participation and final exam.    
McGill University values academic integrity. Therefore all students must understand the meaning and consequences of cheating, plagiarism and other academic offences under the Code of Student Conduct and Disciplinary Procedures (see for more information).

Last update: March 25, 2019