BIOL 551 (Winter)

Principles of Cellular Control


(Given in alternate years; offered in 2019-2020)



Instructors:
J. Vogel
Bellini 269
(514) 398-5880
jackie.vogel@mcgill.ca
P. François Rutherford Physics (514) 398-1635 paul.francois2@mcgill.ca
Other instructors: TBA      
Workload:
3 credits (3-0-6)
Prerequisites:

CHEM 115 or CHEM 120; MATH 133 and MATH 141; PHYS 142; or equivalents; BIOL 201 or BIOL 219 or ANAT 212 / BIOC 212. COMP 204, PHYS 230 and BIOL 319 / PHYS 319 are recommended

Content:

This course attempts to overview fundamental principles of cellular control. Cell cycle control is a major theme. Biological and physical concepts will be brought to bear on control systems in healthy cells, largely based in studies using model organisms. Concepts are related to human cells with relevance to disease (cancer), but disease and cancer are not a focus of this course. It should be remembered that understanding what constitutes a healthy system, and how that state is maintained, is just as critical as understanding the basis of disease. This course is designed with the understanding that students come from both the biological/biomedical sciences and physical sciences and thus the material covered must be accessible to all regardless of their background.

Topics include:
Cell cycle control
Switches, thresholds in biological systems
Oscillators
Symmetry and symmetry breaking
Organization of cellular systems
Biological machines
Methods of analysis

Readings:
Assigned readings are primarily research articles and reviews. Readings from Physical Biology of the Cell (PBoC) will be posted on myCourses. An online version of Molecular Biology of the Cell (4th edition) is available through PubMed and is recommended as a general cell biology reference..
Method:
Faculty lectures and student presentations Two 1.5 hr sessions per week
Evaluation:

Presentation, written assignment, team project and participation.

Last update: March 25, 2019


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