BIOL 313 (Winter)

Eukaryotic Cell Biology



Instructor(s):
S. Weber (Coordinator)
N5/16
(514) 398-2042
steph.weber@mcgill.ca
M. Zetka S3/24 (514) 398-3956 monique.zetka@mcgill.ca
Workload:
3 credits (3-0-6)
Prerequisite(s):
BIOL 200, BIOL 201 or ANAT 212 / BIOC 212; or BIOL 219; BIOL 202
Content:
This course offers an in-depth examination of the structure and function of eukaryotic cells, with an emphasis on experimental design and interpretation. Lectures will explore the molecular mechanisms of various cellular processes, including protein homeostasis, intracellular transport, cytoskeletal dynamics, multicellular organization and cell cycle control. Through assignments and class discussions, students will learn how to read and critically evaluate the primary literature.

Cell Biology

  • Cell theory
  • Light microscopy, including super-resolution techniques
  • Electron microscopy and tomography

Protein homeostasis

  • Protein folding
  • Protein degradation

Intracellular transport

  • Protein sorting
  • Nucleocytoplasmic transport
  • Vesicle trafficking


Cytoskeletal structure and dynamics

  • Polymerization
  • Regulation
  • Molecular motors
  • Cell motility

Multicellular organization

  • Epithelial polarity
  • Intercellular junctions
  • Extracellular matrix

Cell Cycle Control

  • Cell growth and size control
  • S phase, DNA replication
  • Mitosis and meiosis
  • Mechanics of cytokinesis
  • Apoptosis
  • Cancer

Readings:
Pertinent chapters in Molecular Biology of the Cell, 6th edition, by B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts and J.D. Watson.
Method:
There are three hours of lectures each week.
Evaluation:

Assignments based on readings from the primary literature; a mid-term exam and a cumulative final exam


McGill University values academic integrity. Therefore all students must understand the meaning and consequences of cheating, plagiarism and other academic offences under the Code of Student Conduct and Disciplinary Procedures (see http://www.mcgill.ca/integrity/ for more information).

Last update: March 29, 2018