Proper chromosome morphogenesis is required for the faithful segregation of chromosomes during meiosis and can be readily studied in the nematode Caenorhabditis elegans. The research goals of my laboratory are to investigate the function and regulation of meiotic chromosome organization using a combination of genetics, molecular biology, and high-resolution cytogenetics. (For more details, please visit "The Researchers" page on the DBRI site)
Amini, R., Goupil E., Labella S., Zetka M., Maddox, A.S., Labbé, J.C. and N.T. Chartier (2014). C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization. Journal of Cell Biology, 206(1): 129-43.
Bukhari, S.I.A., Vasquez-Rifo, A., Gagné, D., Paquet, E.R., Zetka, M., Robert, C., Masson, J.Y. and M.J. Simard (2012) The microRNA pathway controls germ cells proliferation and differentiation in C. elegans. Cell Research, 6: 1034-45.
Labella, S., Woglar, A., Jantsch, V. and M. Zetka (2011) Polo kinases establish links between meiotic chromosomes and cytoskeletal forces essential for homologue pairing. Developmental Cell, 21: 948-958.
Couteau, F. and M. Zetka (2011) DNA damage during meiosis induces chromatin remodelling and synaptonemal complex disassembly. Developmental Cell, 20: 353-363.
Goodyer, W., Kaitna, S., Couteau, F., Ward, J.D., Boulton, S.J., and Zetka, M. (2008) HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis. Developmental Cell, 14:263-274.
Gilchirst, E.J., O’Neil, N.J., Rose, A.M., Zetka, M.C., and Haughn, G.W. (2006) TILLING is an effective reverse genetics technique for Caenorhabiditis elegans. BMC Genomics, 7.
Couteau, F., and M. Zetka (2005) HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegans. Genes and Development, 19: 2744-2756.
Couteau, F., Nabeshima K., Villeneuve A & Zetka, M. (2004) A Component of C. elegans Meiotic Chromosome Axes at the Interface of Homolog Alignment, Synapsis, Nuclear Reorganization, and Recombination. Current Biology, 14(7): 585-592.
Couteau, F., Goodyer, W. & Zetka, M. (2004) Finding and Keeping Your Partner During Meiosis. Cell Cycle, 3(8), 1014-1016.
Roggo, L., Bernard, V., Kovacs, A.L., Savoy, F., Zetka, M., Rose, A., Wymann, M.P. & Müller, F. (2002) Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane. European Molecular Biology Organization Journal, 21(7): 1673-1683.
Last update: July 13, 2015