Dr. Paul Lasko

Publications

Lasko, P. (2010) Tudor domain. Curr. Biol. 20: R666-R667.

Kugler, J.-M., Woo, J.-S., Oh, B.-H., and Lasko, P. (2010) Competitive regulation of Drosophila Vasa in vivo through paralogous Cullin-RING E3 ligase specificity receptors. Mol. Cell. Biol. 30: 1769-1782.

Kugler, J.-M., Lem, C., and Lasko, P. (2010) Reduced cul-5 activity causes aberrant follicular morphogenesis and germ cell loss in Drosophila. PLoS ONE 5(2): e9048.

Kirino, Y., Vourekas, A., Sayed, N., de Lima Alves, F., Thomson, T., Lasko, P., Rappsilber, J., Jongens, T. A., and Mourelatos, Z.) (2010) Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA 16: 70-78.

Hernández, G., Altmann, M., and Lasko, P. (2010) The origins and evolution of the mechanisms regulating translation initiation in eukaryotes. Trends Biochem. 35: 63-73.

Kilfoil M, Lasko P, and Abouheif E. (2009) Stochastic variation: from single cells to superorganisms. HFSP Journal 1(1): doi:10.2976/1.3223356

Liu, N., Han, H., and Lasko, P. (2009) Vasa promotes Drosophila germ line stem cell differentiation by activating mei-P26 translation through a direct interaction with a U-rich motif in its 3’ UTR. Genes Dev. 23: 2742-2752.

Lasko, P. (2009) Translational control during early development. In Translational Control in Health and Disease. (Hershey, J. W., ed.), vol. 90 of Progress in Molecular Biology And Translational Science. Burlington: Academic Press, p. 211-254.

Maurizil, M., Cavaliere, V., Gamberi, C., Lasko, P., Gargiulo, G., and Taddei, C. (2009) Vasa protein is localized in the germ cells and in the oocyte associated pyriform follicle cells during early oogenesis in the lizard Podarcis sicula. Dev. Genes Evol. 219: 361-367.

Pare, J. M., Tahbaz, N., LaPointe, P., Lasko, P., and Hobman, T. C. (2009) Hsp90 regulates the function of Argonaute proteins and their recruitment to stress granules and P-odies. Mol. Biol. Cell 20: 3273-3284.

Moore, J., Han, H., and Lasko, P. (2009) Bruno negatively regulates germ cell-less expression in a BRE-independent manner. Mech. Dev. 126: 503-516.

Moore, J. and Lasko, P. (2009) Breaking the A chain: regulating mRNAs in development through CCR4 deadenylase. F1000 Biology Reports 1: 20.

Kugler, J.-M. and Lasko, P. (2009) Localization, anchoring, and translational control of oskar, gurken, bicoid, and nanos mRNA during Drosophila oogenesis. Fly, 3: 15-28.

Solana, J., Lasko, P., and Romero, R. (2009) Spoltud-1 is a chromatoid body component required for planarian long-term stem cell self-renewal. Dev. Biol., 328: 410-421.

Kugler, J.-M., Chicoine, J., and Lasko, P. (2009) Bicaudal-C associates with a Trailer Hitch/Me31B complex and is required for efficient Gurken secretion. Dev. Biol. 328: 160-172.

Moore, J. and Lasko, P. (2009) Translational control in invertebrate development. In Handbook of Cell Signaling (ed. N. Sonenberg; Academic Press, New York), pp. 2323-2328.

Stein, D. and Lasko, P. (2008) The 30th Anniversary Crete Fly Meeting: from individual molecules to 12 genomes, and beyond. Fly 2: 326-333.

Dansereau, D. A., and Lasko, P. (2008) An isoform of RanBPM regulates cell shape, arrangement and capacity of the female germline stem cell niche in Drosophila. J. Cell Biol. 182: 963-977.

Thomson, T., Liu, N., Arkov, A., Lehmann, R., and Lasko, P. (2008) Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins.  Mech. Dev. 125: 865-873.

Hanyu-Nakamura, K., Sonobe, H., Tanigawa, A., Lasko, P., and Nakamura, A. (2008) Drosophila polar granule component encodes a small protein that acts as a germ cell specific P-TEFb inhibitor. Nature 451: 730-733.

Dansereau, D. A. and Lasko, P. (2008) The development of germline stem cells in Drosophila.  In: Hou, S. X. and Singh, S. R. (eds.) Methods in Molecular Biology, volume 450, Germline Stem Cells. Totowa, NJ: Humana Press, p. 3- 26.

Chicoine J, Benoit P, Gamberi C, Paliouras M, Simonelig M, Lasko P. (2007) Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression. Dev Cell. 13:691-704.

Chicoine, J., Benoit, P., Paliouras, M., Gamberi, C., Simonelig, M., and Lasko, P. Autoregulation of Bicaudal-C expression is essential for embryo patterning and reveals Bicaudal-C as an ovarian activator of the CCR4-NOT deadenylation complex in Drosophila. Submitted for publication.

Hanyu-Nakamura, K., Sonobe, H., Tanigawa, A., Lasko, P., and Nakamura, A. Drosophila polar granule component encodes a small protein that acts as a germ cell specific P-TEFb inhibitor.  Submitted for publication.

Levitin, A., Laforest, M. J., Tettweiler, G., Oberholzer, U., Marcil, A., Alarco, A.-M., Thomas, D. Y., Lasko, P., and Whiteway, M. (2007)  Drosophila melanogaster Thor and response to Candida albicans infection. Eukaryotic Cell 6: 658-663.

Lasko, P. and Sonenberg, N. (2007) Coordinated transcriptional and translational control in metabolic homeostasis in flies. Genes Dev. 21: 235-237.

Tettweiler, G. and Lasko, P. (2007) Investigating translation initiation using Drosophila molecular genetics. Meth. Enzymol., 429: 227-242.
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Dansereau, D. A. and Lasko, P. (2007) The development of germline stem cells in Drosophila. In: Methods in Molecular Biology: Germline Stem Cell Protocols. Humana Press.

Levine, S. L., Sunday, S., Dörig, R. E., Suter, B., and Lasko, P. (2007) Genetic maps of the proximal half of chromosome arm 2L of Drosophila melanogaster. Genome 50: 137-141.

Cho, P., Gamberi, C., Cho-Park, Y. A., Cho-Park, I. B., Lasko, P., and Sonenberg, N. (2006) Cap-dependent translational inhibition establishes two opposing morphogen gradients in the Drosophila embryo. Curr. Biol. 16: 2035-2041.

Tettweiler, G. and Lasko, P. (2006) A new model for translational regulation of specific mRNAs. Trends Biochem. Sci. 31: 607-610.

Xing, Y., Gosden, R., Lasko, P., and Clarke, H. (2006) Murine homologues of the Drosophila gustavus gene are expressed in ovarian granulosa cells. Reproduction 131: 905-915.

Linder, P. and Lasko, P. (2006)  Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa. Cell 125: 219-221.

Gamberi, C., Johnstone, O., and Lasko, P. (2006) Drosophila RNA binding proteins. Int. Rev. Cytol. 248: 43-139.

Cho P.F., Gamberi C., Cho-Park Y.A., Cho-Park I.B., Lasko P., Sonenberg N. (2006) Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos. Curr Biol. 16:2035-41.

Tettweiler G., Lasko P. (2006) A new model for translational regulation of specific mRNAs. Trends Biochem Sci. 31:607-10.

Xing, Y., Gosden, R., Lasko, P., and Clarke, H. (2006) Murine homologues of the Drosophila gustavus gene are expressed in ovarian granulosa cells. Reproduction 131: 905-915.
 
Linder, P. and Lasko, P. (2006) Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa. Cell 125: 219-221.
 
Gamberi, C., Johnstone, O., and Lasko, P. (2006) Drosophila RNA binding proteins. Int. Rev. Cytol. 248: 43-139.
 
Lasko, P., Cho, O., Poulin, F., and Sonenberg, N. (2005) Contrasting mechanisms of regulating translation of specific Drosophila germ line mRNAs at the level of 5’ cap structure binding. Biochem. Soc. Trans. 33: 1544-1546.
 
Tettweiler, G., Miron, M., Jenkins, M., Sonenberg, N., and Lasko, P. (2005) Starvation and oxidative stress resistance in Drosophila are mediated through eIF4E-binding protein. Genes Dev. 19: 1840-1843.

Thomson, T. and Lasko, P. (2005) Tudor and its domains: germ cell formation from a Tudor perspective. Cell Research 15: 281-291.

Cho, P., Poulin, F., Cho-Park, Y. A., Cho-Park, I. B., Chicoine, J. D., Lasko, P. and Sonenberg, N. (2005) A new paradigm for translational control: inhibition of caudal via 5’-3’ tethering by Bicoid and the eIF4E cognate 4EHP. Cell 121: 411-423.

Johnstone, O., Deuring, R., Bock, R., Linder, P., Fuller, M., and Lasko, P. (2005) Belle is a Drosophila DEAD-box protein required for viability and in the germ line. Dev. Biol. 277: 92-101.

Dansereau, D. A., McKearin, D., and Lasko, P. (2005)  Oogenesis. In Gilbert, L., Gill, S., and Iatrou, K. (eds.) Comprehensive Insect Physiology, Biochemistry, Pharmacology and Molecular Biology  (Elsevier Press: Amsterdam), p. 39-85.

Thomson, T. and Lasko, P. (2004) Drosophila tudor is essential for polar granule assembly and pole cell specification, but not for posterior patterning. Genesis 40: 164-170.

Johnstone, O. and Lasko, P.  (2004) Interaction with eIF5B is essential for Vasa function during development.  Development 131: 4167-4178.

Schuetze, C., Akit-Peters, M., Duong, J.-J., Cavey, M., Dörig, R., Lasko, P., and Suter, B. (2004) Map positions of third chromosome female sterile and lethal mutations of Drosophila melanogaster.Genome 47:832-838.

Boulanger, M.-C., Branscombe Miranda, T., Clarke, S., DiFruscio, M., Suter, B., Lasko, P., and Richard, S. (2004)  Characterization of Drosophila protein arginine methyltransferases DART1 and DART4. Biochem. J. 379: 283-289.

Roy, G., Miron, M., Khaleghpour, K., Lasko, P., and Sonenberg, N. (2004) The Drosophila PABP-interacting protein, dPaip2, is a novel effector of cell growth. Mol. Cell. Biol. 24: 1143-1154.

Miron, M., Lasko, P., and Sonenberg, N. (2003) Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila. Mol. Cell. Biol. 23: 9117-9126.

Lasko, P. (2003) Cup-ling oskar localization to translational control. J. Cell Biol. 163: 1189-1191.

Lasko, P. (2003) Ribosomes rule: translation, not transcription, is the primary target of two major intercellular signaling pathways. Dev. Cell 5: 671-672.

Liu, N., Dansereau, D. A., and Lasko, P. (2003)Fat Facets interacts with Vasa in the Drosophila pole plasm and protects it from degradation. Curr. Biol. 13: 1905-1909.

Lasko, P. (2003) Gene regulation at the RNA layer: RNA-binding proteins in intercellular signaling networks.  Science STKE 179: RE6.

Huang, H., Paliouras, M., Rambaldi, I., Lasko, P., and Featherstone, M. (2003) Non-muscle myosin promotes cytoplasmic localization of PBX. Mol. Cell. Biol. 23: 3636-3645.

DiFruscio, M., Styhler, S., Wikholm, E., Boulanger, M.-C., Lasko, P., and Richard, S. (2003) kep1 interacts genetically with dredd/Caspase-8: Kep1 regulates the balance of the dredd isoforms. Proc. Natl. Acad. Sci. USA 100: 1814-1819.

Lasko, P. (2003) Translational control in invertebrate development.  In Handbook of Cell Signaling (ed. N. Sonenberg, Academic Press, New York), vol. 3, p. 327-330.

Styhler, S., Nakamura, A., and Lasko, P. (2002) VASA localization requires the SPRY-domain and SOCS-box containing protein, GUSTAVUS. Dev. Cell 3: 865-876.

Larocque, D., Pilotte, J., Chen, T., Cloutier, F., Massie, B., Pedraza, L., Couture, R., Lasko, P., Almazan, G., and Richard, S. (2002) Nuclear retention of MBP RNA in the quaking viable mice. Neuron 36: 815-829.

Lasko, P. (2002) Diabetic flies? Using Drosophila melanogaster to understand the causes of monogenic and genetically complex diseases. Clin. Genet. 62: 358-367.

Lachance, P. E. D., Miron, M., Raught, B., Sonenberg, N. and Lasko, P. (2002) Phosphorylation of eukaryotic initiation factor 4E (eIF4E) is critical for growth. Mol. Cell. Biol. 22: 1656-1663.

Johnstone, O. and Lasko, P. (2001) Translational regulation and RNA localization in Drosophila oocytes and embryos. Annu. Rev. Genet. 35: 365-406.

Miron, M., Verdú, J., Lachance, P. E. D., Birnbaum, M. J., Lasko, P., and Sonenberg, N. (2001) The translational inhibitor 4E-BP is an effector of PI3K/Akt signaling in Drosophila, and regulates cell growth. Nature Cell Biol. 3: 596-601.

Butler, H., Levine, S., Wang, X., Bonyadi, S., Lasko, P., Suter, B., and Dörig, R. (2001) Map position and expression of the genes in the 38 region of Drosophila. Genetics 158: 1597-1614.

Lasko, P. (2000) Drosophila embryo: maternal interactions in specification of the anterior-posterior axis.  Encyclopedia of Life Sciences, Macmillan, London, and published on-line on www.els.net.

Lasko, P. (2000) The Drosophila genome: translation factors and RNA binding proteins. J. Cell Biol. 150: F51-F56.

Sigrist, S. J., Thiel, P. R., Reiff, D. F., Lachance, P., Lasko, P., and Schuster, C. M. (2000) Postsynaptic translation controls morphology and efficacy of Drosophila neuromuscular junctions. Nature 405: 1062-1065.

Adams, M. D., Celniker, S. E., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S., Li, P. W., Galle, R. F., George, R. A., Hoskins, R. A., Lewis, S., Richards, S., Ashburner, M., Henderson, S. N., Wortman, J. R., Yandell, M. D., Zhang, Q., Chen, L. X., Brandon, R. C., Rogers, Y.-H. C., Blazej, R. G., Champe, M., Pfeiffer, B. D., Wan, K. H., Doyle, C., Baxter, E. G., Nelson, C. R., Gabor Miklos, G. L., Abril Ferrando, J. F., Agbayani, A., An, H.-J., Ballew, R. M., Basu, A., Baxendale, J., Bayraktaroglu, L., Beasley, E. M., Beeson, K. Y., Benos, P. V., Berman, B. P., Bhandari, D., Bolshakov, S., Borkova, D., Botchan, M. R., Bouck, J., Brokstein, P., Burtis, K. C., Busam, D., Butler, H., Cadieu, E., Cherry, J. M., Dahlke, C., Davies, P., de Pablos, B., Delcher, A., Deng, Z., Deslattes Mays, A., Dew, I., Dietz, S. M., Dodson, K., Doup, L., Downes, M., Dugan-Rocha, S., Dunkov, B. C., Dunn, P., Durbin, K. J., Evangelista, C. C., Ferraz, C., Fleischmann, W., Fosler, C., Gabrielian, A. E., Garg, N., Gelbart, W. M., Glasser, K., Glodek, A., Gong, F., Gorrell, J. H., Gu, Z., Guan, P., Harris, M., Harris, N. L., Harvey, D., Heiman, T. J., Helt, G., Hernandez, J. R., Houck, J., Houston, K. A., Howland, T. J., Kalush, F., Karpen, G. H., Ke, P., Kennison, J. A., Ketchum, K. A., Kimmel, B., Kodira, C. D., Kraft, C., Kravitz, S., Kulp, D., Lai, Z., Lasko, P., Lei, Y., Levitsky, A. A., Li, J., Li, Z., Liang, Y., Lin, X., Liu, X., McIntosh, T. C., McPherson, D., Merkulov, G., Milshina, N. V., Mobarry, C., Morris, J., Moshrefi, A., Mount, S. M., Murphy, L., Muzny, D. M., Nelson, D. L., Nelson, D. R., Nixon, K., Nusskern, D. R., Pacleb, J. M., Palazzolo, M., Pan, S., Pollard, J., Reese, M., Reinert, K., Remington, K., Saunders, R. D. C., Shen, H., Shue, C., Sidén-Kiamos, I., Simpson, M., Skupski, M. P., Smith, T., Spradling, A. C., Stapleton, M., Sun, E., Sutton, G. G., Turner, R., Venter, E., Wang, A. H., Wang, X., Wang, Z.-Y., Wassarman, D. A., Weinstock, G. M., Woodage, T., Worley, K. C., Wu, D., Yang, S., Yao, A. Q., Ye, J., Zhan, M., Zhang, G., Zhao, Q., Zheng, E., Zheng, H. X., Zhong, F. N., Zhong, W., Zhou, X., Zhu, S., Zhu, X., Smith, H. O., Gibbs, R., Myers, G., Rubin, G. M., and Venter, J. C.  (2000) The genome sequence of Drosophila melanogaster. Science 287: 2185-2195.

Carrera, P., Johnstone, O., Nakamura, A., Casanova, J., Jäckle, H., and Lasko, P. (2000) VASA mediates translation through interaction with a Drosophila yIF2 homolog. Mol. Cell 5: 181-187.

Saffman, E. E. and Lasko, P. (1999) Germ line development in vertebrates and invertebrates. Cell. Mol. Life Sci. 55: 1141-1163.

Lasko, P. (1999) RNA sorting in Drosophila oocytes and embryos. FASEB J. 13: 421-433.

Lasko, P. (1999) Germ cell, line. In: Creighton, T. E., ed., The Encyclopedia of Molecular Biology, 1004-1006. John Wiley and Sons.

Kobayashi, S., Amikura, R., Nakamura, A., and Lasko, P. F. (1999) Techniques for analyzing protein and RNA distribution in Drosophila ovaries and embryos at structural and ultrastructural resolution.  In: Richter, J., ed., Advances in molecular biology: a comparative methods approach to the study of oocytes and embryos. Oxford University Press.