Publications (since 1989)
Ken Hastings

Hastings, K.E.M., Hallauer, P.L., Peterson, A.C., Karpati, G., and Koppe, R. (1989) Differential expression of skeletal muscle troponin I genes, in "Cellular and Molecular Biology of Muscle Development" pp 759-766 (Kedes,L.H., and Stockdale,F.E., eds.) Alan R. Liss, Inc., New York

Koppe, R., Hallauer, P.L., Karpati, G., and Hastings, K.E.M. (1989) cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs. J. Biol. Chem. 264, 14327-14333) link to NCBI PubMed entry

Schwob, N.G., Nalbantoglu, J., Hastings, K.E.M., Mikkelson, T.,and Cashman, N.R. (1989) DNA cytosine methylation in brain of patients with Alzheimer's disease. Annals of Neurology 28, 91-94 link to NCBI PubMed entry

Shoubridge, E.A., Karpati, G., and Hastings, K.E.M. (1990) Deletion mutants are functionally dominant over coexisting wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease. Cell 62, 43-49 link to NCBI PubMed entry

Hastings, K.E.M., Koppe, R.I, Marmor, E., Bader, D., Shimada, Y., and Toyota, N. (1991) Structure and developmental regulation of troponin I isoforms: cDNA clone analysis of avian cardiac troponin I mRNA. J.Biol. Chem. 266, 19659-19665 link to NCBI PubMed entry

Hastings, K.E.M. (1992) Gene expression in motor neurons, in "Handbook of Amyotrophic Lateral Sclerosis" pp 709-737 (Smith,R.A., ed.) Marcel Dekker, Inc., New York

Gorza, L., Ausoni, S., Merciai, N., Hastings, K.E.M., and Schiaffino, S. (1993) Regional differences in troponin I isoform switching during rat heart development. Devel. Biol. 156, 253-264 link to NCBI PubMed entry

Meedel, T.H., and Hastings, K.E.M. (1993) Striated muscle-type tropomyosin in a chordate smooth muscle, ascidian body-wall muscle. J. Biol. Chem. 268, 6755-6764. link to NCBI PubMed entry

Hallauer, P.L., Bradshaw, H.L., and Hastings, K.E.M. (1993) Complex fiber type specific expression of fast skeletal muscle troponin I gene constructs in transgenic mice. Development 119, 691-701 link to NCBI PubMed entry

Guénet, J.-L., Simon-Chazottes, D., Gravel, M., Hastings, K.E.M., and Schiaffino, S. (1996) Cardiac and skeletal muscle troponin I isoforms are encoded by a dispersed gene family on mouse chromosomes 1 and 7. Mamm. Genome 7, 13-15 link to NCBI PubMed entry

Hodgson, P.A., Leaver, M.J., George, S.G., MacLean, D.W., and Hastings, K.E.M. (1996) Molecular cloning of troponin I expressed in fast white muscle of a teleost fish, the Atlantic herring (Clupea harengus L.). Biochim. Biophys. Acta. 1306, 142-146 link to NCBI PubMed entry

Hastings, K.E.M. (1996) Strong evolutionary conservation of broadly expressed protein isoforms in the troponin I gene family and other vertebrate gene families. J. Mol. Evol. 42, 631-640 link to NCBI PubMed entry

Hastings, K.E.M. (1997) Molecular evolution of the vertebrate troponin I gene family. Cell Structure and Function 22, 1-7 link to NCBI PubMed entry

Larochelle, N., Lochmuller, H., Zhao, J., Jani. A., Hallauer, P.L., Hastings, K.E.M., Massie, B., Prescott, S., Petrof, B.J., Karpati, G., and Nalbantoglu, J. (1997) Efficient muscle-specific transgene expression after adenovirus-mediated gene transfer in mice using a 1.35 kb muscle creatine kinase promoter/enhancer. Gene Therapy 4, 465-472. link to NCBI PubMed entry

MacLean, D.W., Meedel, T.H., and Hastings, K.E.M. (1997) Tissue-specific alternative splicing of ascidian troponin I isoforms: redesign of a protein isoform-generating mechanism during chordate evolution. J. Biol. Chem. 272, 32115-32120 link to NCBI PubMed entry

Ito, H., Hallauer, P.L., Hastings, K.E.M., and Tremblay, J.P. (1998) Prior culture with concanavalin A increases intramuscular migration of transplanted myoblasts. Muscle & Nerve 21, 291-297 link to NCBI PubMed entry

Hallauer, P.L., Karpati, G., and Hastings, K.E.M. (2000) Skeletal muscle gene transfer: regeneration-associated deregulation of fast troponin I fiber type specificity. Am. J. Physiol: Cell Physiol. 278, 1266-1274 link to NCBI PubMed entry

Hallauer, P.L., and Hastings, K.E.M. (2000) Human cytomegalovirus IE1 promoter/enhancer drives variable gene expression in all fiber types in transgenic mouse skeletal muscle. BMC Genetics 1:1 link to NCBI PubMed entry

Vandenberghe, A.E., Meedel, T.H., and Hastings, K.E.M. (2001) mRNA 5’-leader trans-splicing in the chordates. Genes & Dev. 15, 294-303 link to NCBI PubMed entry

Hallauer, P.L., and Hastings, K.E.M. (2002) Coregulation of fast contractile protein transgene and glycolytic enzyme expression in mouse skeletal muscle. Am. J. Physiol: Cell Physiol. 282, C113-124 link to NCBI PubMed entry

Hallauer P.L., and Hastings K.E.M. (2002) TnIfast IRE enhancer: multistep developmental regulation during skeletal muscle fiber type differentiation. Dev Dyn. 224, 422-431 link to NCBI PubMed entry

Dehal P. et al (2002) The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins. Science 298, 2157-2167 link to NCBI PubMed entry

Chiba S., Awazu S., Itoh M., Chin-Bow S.T., Satoh N., Satou Y., and Hastings K.E.M. (2003) A genomewide survey of developmentally relevant genes in Ciona intestinalis. IX. Genes for muscle structural proteins. Dev Genes Evol 213, 291-302 link to NCBI PubMed entry

Cleto C., Vandenberghe A., MacLean D.W., Pannunzio P., Tortorelli C., Meedel T.H., Satou Y., Satoh N., and Hastings K.E.M. (2003) Ascidian larva reveals ancient origin of vertebrate-skeletal-muscle troponin I characteristics in chordate locomotory muscle. Mol Biol Evol 20, 2113-2122 link to NCBI PubMed entry

Hastings K.E.M (2005) SL trans-splicing: easy come or easy go? Trends in Genetics 21, 240-247 link to NCBI PubMed entry

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