Publications


Journal articles

Recent Duplication and Functional Divergence in Parasitic Nematode Levamisole-Sensitive Acetylcholine Receptors.
Duguet T.B., Charvet C.L., Forrester S.G., Wever C.M., Dent J.A., Neveu C., Beech R.N. (2016) PLoS Negl Trop Dis. 14:10(7):e0004826.

The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules.
Feingold, D., Starc, T, O’Donnell, M.J., Nilson, L., and Dent, J.A. (2016) Journal of Experimental Biology 219: 2629-2638.

Acetylcholine-Gated Chloride Channels as Potential Anthelmintic Drug Targets.
Wever, C.M., Farrington, D. and Dent, J.A. (2015) The Validation of Nematode-Specific PLoS ONE, 10: e0138804 doi:10.1371/journal.pone.0138804.

A dyf-7 haplotype causes sensory neuron defects and is associated with macrocyclic lactone resistance worldwide in the nematode parasite Haemonchus contortus.
Urdaneta-Marquez, L., Bae, S.H., Janukavicius, P., Beech, R., Dent, J., Prichard, R. (2014) International journal of Parasitology 44: 1063–1071

Molecular Cloning and Characterization of Novel Glutamate-Gated Chloride Channel Subunits from Schistosoma mansoni.
Dufour, V., Beech, R.N., Wever, C., Dent, J.A., Geary, T.G. PLoS Pathology 9(8): e1003586. (2013) doi:10.1371/journal.ppat.1003586

Stoichiometry of the Human Glycine Receptor Revealed by Direct Subunit Counting.
Durisic, N., Godin, A.G., Wever, C.M., Heyes, C.D., Lakadamyali, M and Dent, J.A. (2012) Journal of Neuroscience 32: 12915–12920.

Nematode parasite genes: what's in a name?
Beech, R.N., Wolstenholme, A.J., Neveu, C. and Dent, J.A. (2010) Trends in Parasitology 26: 334-340.

Aplysia cys-loop Glutamate-Gated Chloride Channels Reveal Convergent Evolution of Ligand Specificity.
Kehoe, J., Buldakova, S., Acher, F., Dent, J.A., Bregestovski, P., and Bradley (2009) J. Journal of Molecular Evolution 69: 125-141.

Chapter II: The evolution of pentameric ligand-gated ion channels. In Insect Nicotinic Acetylcholine Receptors.
Dent, J.A. (2009) S. Thany, ed., Landes Bioscience, Georgetown TX.

Molecular characterization of a pH-gated chloride channel from Sarcoptes scabiei.
Mounsey, K.E., Dent, J.A., Holt, D.C. McCarthy, J. Currie, B.J. and Walton, S.F. (2007) Invertebrate Neuroscience 7: 149-156.

The serotonin receptor SER-1 (5HT2ce) contributes to the regulation of locomotion in Caenorhabditis elegans.
Dernovici, S., Starc, T., Dent, J.A. and Ribeiro, P. (2007) Journal of  Neurobiology 67: 189-204. Published Online: 7 Dec 2006

Evidence for a diverse cys-loop ligand-gated ion channel superfamily in early bilateria.
Dent, J.A. (2006) Journal of  Molecular Evolution 62: 523-535.

Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans.
De Jong, L., Meng, Y., Dent, J.A. & Hekimi, S.(2004) Genetics 168: 845-854.

Genomic organisation of an avermectin receptor subunit from Haemonchus contortus and the expression of its promoter region in Caenorhabditis elegans.  
Liu, J., Dent, J.A., Beech, R.N. & Prichard, R.K. (2004) Molecular and  Biochemical Parasitology 134: 267-274.

Haemonchus contortus: HcGluCla expressed in Xenopus oocytes forms a glutamate-gated ion channel that is activated by ibotenate and the antiparasitic drug ivermectin.
Forrester, S.G., Prichard, R.K. Dent, J.A. & Beech, R.N. (2003) Molecular and Biochemical Parasitology 129: 115-121.

Regulation of intermuscular electrical coupling by the Caenorhabditis elegans innexin inx-6
Li, S., Dent, J.A. & Roy, R. (2003) Molecular Biology of the Cell 14: 2630-2644.

Reversal frequency in C. elegans represents an integrated response to the state of the worm and its environment.
Zhao, B., Khare, P., Feldman, L. & Dent, J.A. (2003) Journal of Neuroscience 23: 5319-5328.

What can Caenorhabditis elegans tell us about nematocides and parasites?
Dent, J.A. (2001) Biotechnology and Bioprocess Engineering 6: 1-6.

The genetics of ivermectin resistance in Caenorhabditis elegans.
Dent, J.A., Smith, M., Vassilatis, D.K. and Avery, L. (2000) Proc. Nat. Acad. Sci. 97(6): 2674-2679.

EAT-20, a novel transmembrane protein with EGF motifs, is required for efficient feeding in Caenorhabditis elegans.
Shibata, Y., Fujii, T., Dent, J.A., Fujisawa, H., and Takagi, S. (2000) Genetics 154(2): 635-646.

A mutation in the C. elegans EXP-2 potassium channel that alters feeding behavior.
Davis, M.W., Fleischauer, R., Dent, J.A., Joho, R.H. and Avery, L. (2000) Science 286(5449):2501-2504.

Post-embryonic expression pattern of C. elegans let-60 ras reporter constructs.
Dent, J.A., Han, M. (1998) Mechanisms of Development 72: 179-182.

avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans.
Dent, J.A., Davis, M.W. and Avery, L. (1997) EMBO Journal 16: 5867-5879.

Abstracts

Using GluCla2 to turn off excitable cells
Joe Dent, Leon Avery.

A defined medium for the pharynx.
Joe Dent and Leon Avery

Last update: Sept.13, 2017