The Cristescu Lab



Lab Members



Frédéric J.J. Chain
Postdoctoral Fellow
 



Environmental stress and copy-number changes
I am currently a postdoc in the field of environmental genomics investigating evolutionary questions relating to genomics, conservation and speciation. I am involved in numerous genomics and transcriptomics projects analyzing polymorphisms and divergence in sticklebacks, evolution of duplicate genes inXenopus, metabarcoding data for monitoring biodiversity and detecting invasive species, and the effects of environmental stressors on mutation rates in Daphnia. A particular interest of mine is the evaluation of structural variations such as CNVs and their potential role in differentiation and environmentally associated adaptation. Further investigations include the analysis of orphan genes, sex chromosomes, introns, transposable elements and the interplay between structural variants and gene expression. I have recently co-edited a Frontiers research topic entitled Structural variations in genomes: ecological and evolutionary implications. For more please see http://www.evolbio.mpg.de/~chain/

Flynn JM, Brown EA, Chain FJJ, MacIsaac HJ and Cristescu ME. (2015). Toward
accurate molecular identification of species in complex environmental samples: testing the performance of sequence filtering and clustering methods
. Ecology and Evolution.

Brown EA, Chain FJJ, Crease TJ, MacIsaac HJ and Cristescu ME. (2015). Divergence thresholds and divergent biodiversity estimates: can metabarcoding reliably describe zooplankton communities? Ecology and Evolution.

Feulner PGD*, Chain FJJ*, Panchal M*, Huan Y, Eizaguirre C, Kalbe M, Lenz TL, Samonte IE, Stoll M, Bornberg-Bauer E., Reusch TBH and Milinski M. (2015) Genomics of divergence along a continuum of parapatric population differentiation. PLoS Genetics. *Shared first authors

Chain FJJ*, Feulner PGD*, Panchal M*, Eizaguirre C, Kalbe M, Lenz TL, Samonte IE, Stoll M, Bornberg-Bauer E., Milinski M and Reusch TBH. (2014) Extensive copy-number variation of young genes across stickleback populations. PLoS Genetics. *Shared first authors

Chain FJJ and Feulner PGD. (2014). Ecological and evolutionary implications of genomic structural variations. Front. Genet.

Zhan A, He Song, Brown E, Chain FJJ, Therriault TW, Abbott CL, Heath DD, Cristescu ME and MacIsaac HJ. (2014). Reproducibility of pyrosequencing data for biodiversity assessment in complex communities. Methods in Ecology and Evolution.

Guo B, Chain FJJ, Bornberg-Bauer E, Leder EH and Merilä J. (2013). Genomic divergence between nine- and three-spined sticklebacks. BMC Genomics.

Stiebens V, Merino SE, Roder C, Chain FJJ, Lee PLM and Eizaguirre C (2013). Living on the edge: how philopatry maintains adaptive potential. Proc. R. Soc. B

Bewick AJ, Chain FJJ, Zimmerman LB, Sesay A, Gilchrist MJ, Owens N, Seifertova E, Krylov V, Macha J, Tlapakova T, Kubickova S, Cernohorska H, Zarsky V, Evans BJ (2013). A large pseudoautosomal region on the sex chromosomes of the frog Silurana tropicalis. Genome Biology and Evolution

Shen JJ, Dushoff J, Bewick AJ, Chain FJJ and Evans BJ (2013). Genomic dynamics of transposable elements in the Western Clawed Frog (Silurana tropicalis). Genome Biology and Evolution.

Stiebens VA, Merino SE, Chain FJJ and Eizaguirre C (2013). Evolution of MHC class I genes in the endangered loggerhead sea turtle (Caretta caretta) revealed by 454 amplicon sequencing. BMC Evolutionary Biology.

Feulner PGD*, Chain FJJ*, Panchal M*, Eizaguirre C, Kalbe M, Lenz TL, Mundry M, Samonte IE, Stoll M, Milinski M, Reusch TBH, Bornberg-Bauer E (2013). Genome-wide patterns of standing genetic variation in a marine population of three-spined sticklebacks. Molecular Ecology. *Shared first authors

Bewick AJ, Chain FJJ, Heled J and Evans BJ (2012). The Pipid root. Systematic Biology.

Chain FJJ, Dushoff J and Evans BJ (2011). The odds of duplicate gene persistence after polyploidization. BMC Genomics.

Chain FJJ, Ilieva D and Evans BJ (2008). Single-species microarrays and comparative transcriptomics. PLoS One.

Chain FJJ, Ilieva D and Evans BJ (2008). Duplicate gene evolution and expression in the wake of vertebrate allopolyploidization. BMC Evolutionary Biology.

Chain FJJ and Evans BJ (2006). Multiple mechanisms promote the retained expression of gene duplicates in the tetraploid frog Xenopus laevis. PLoS Genetics.

 

   
Contact Information
Frederic Chain
Postdoctoral Fellow
McGill University

Department of Biology
McGill University
1205 ave Docteur Penfield
Room N6/9
Montréal, Québec

frederic.chain[AT]mail.mcgill.ca