Dr. Howard Bussey
Emeritus Professor


Mailing address
Dr. H. Bussey
McGill University
Department of Biology
1205 Dr Penfield Avenue, N5/16B
Montreal (QC) H3A 1B1 CANADA

*Not accepting Grad students

 


Yeast Genomics

Molecular biology of protein secretion and cell surface assembly in yeast.



Publications


Bussey, H., Logan, M.R., Nguyen, T., Szapiel, N.,Knockleby, J., Por, H.T., Zadworny, M., Neszt, M., Harrison, P., Mandato, C.A., Vogel, J., Lesage, G. (2008) Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. BMC Genomics, v9, Article number 336.

Bussey, H., Tarassov, K., Messier,V., Landry, C.R., Radinovic, S., Serma, M., Shames I., Malitskaya, Y., Vogel, J., and Michnick, S.W.  (2008) An in vitro map of the yeast protein interactome. Science,v. 320: 1465-1470.

Bussey, H., Federova, N.D., Khaldi, N., Joardar, V.S., Maiti, R., Amedeo, P., Anderson, M.J., Crabtree, J., Silva, J.C., Badger, J.H., Albarraq, A., Angiuoli, S., Bowyer, P., Cotty, P.J., Dyer, P.S., Egan, A., Galens, K., Fraser-Liggett, C.M., Haas, B.J., Inman, J.M., Kent, R., Lemieux, S., Malavazi, I., Orvis, J., Roemer, T., Ronning, C.M., Sundaram, J.P., Sutton, G., Turner, G., Venter, J.C., White, O.R., Whitty, B.R., Youngman, P., Wolfe, K.H., Goldman, G.H., Wortman, J.R., Jiang,B., Denning, D.W., Nierman, W.C. (2008) Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus. PLoS Genetics, v.4(4): e100046.

Boone, C., Bussey, H. and Andrews, B. (2007) Exploring genetic interactions and networks in yeast. Nature Reviews Genetics, Vol. 8, 437-449.

Quan, X., Yu, J., Bussey, H. and Stochaj, U. (2007) The localization of nuclear importers of the importin-beta family is regulated by Snf1 kinase, nutrient supply and stress. Biochemistry and Biophysics Acta – Molecular Cell Research, Vol. 1773, 1052-1061.

Xu, D., Jiang, B., Ketela, T., Lemieux, S., Veillette, K., Martel, N., Davison, J., Sillaots, S., Trosok, S., Bachewich,C., Bussey, H., Youngman, P. and Roemer, T. (2007) Genome-wide fitness test and mechanism–of-action studies of inhibitory compounds in Candida albicans. PLOS-Pathogenesis, Vol. 3, 0835-0848.

Parsons, A.B., Bussey, H. and Boone, C.). Functional genomic approaches to fungal pathogenesis, drug target validation, and antifungal drug discovery. In: Molecular Principles of Fungal Pathogenesis,2006, Chapter 42, pages 627-642. (ed. J. Heitman et al.) ASM Press.

Protchenko, O., Rodriguez- Saurez, R., Androphy, R., Bussey, H. and C.C. Philpott. (2006) A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum. Journal of Biological Chemistry v.281, pp. 21445-21457.

Lesage, G. and Bussey, H. (2006) Cell wall assembly in Saccharomyces cerevisiae. Microbiology and Molecular Biology Reviews v.70, pp.317-343.

Bussey, H., B. Andrews, B. and Boone, C. (2006) From worm genetics to complex human diseases. Nature Genetics, v.38, pp. 862-863.

Bussey, H. (2005) Host-microbe interactions: fungi. Editorial overview. Current Opinion in Microbiology 8: 359-361.

Zhang L.V., King O.D., Wong S.L., Goldberg D.S., Tong A.H.Y., Lesage G., Andrews B., Bussey H., Boone C. and Roth F.P. (2005) Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. Journal of Biology, 4:6.

Lesage, G., Shapiro, J., Specht, C.A., Sdicu, A.M., Menard, P., Hussein, S., Tong, A.H., Boone, C., Bussey, H. (2005). An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae. BMC.Genet. 6, 8. [Supplementary data]

Firon, A., Lesage, G., Bussey, H. (2004). Integrative studies put cell wall synthesis on the yeast functional map. Curr.Opin.Microbiol. 7, 617-623.

Herrero, A.B., Magnelli, P., Mansour, M.K., Levitz, S.M., Bussey, H. & Abeijon, C. (2004) Null mutants of the Candida albicans KRE5 gene are avirulent and have altered cell wall composition and hyphal formation properties.  Eukaryotic Cell v.3, 2004, pp. 1423-1432

Lesage, G., Sdicu, A.M., Menard, P., Shapiro, J., Hussein, S., Bussey, H. (2004). Analysis of ß-1,3 glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin.
Genetics 167, 35-49. [Supplementary data]

Tong, A.H., Lesage, G., Bader, G.D., Ding, H., Xu, H., Xin, X., Young, J., Berriz, G.F., Brost ,R.L., Chang, M., Chen, Y., Cheng, X., Chua, G., Friesen, H., Goldberg, D.S., Haynes, J., Humphries, C., He, G., Hussein, S., Ke, L., Krogan, N., Li, Z., Levinson, J.N., Lu, H., Menard, P., Munyana, C., Parsons, A.B., Ryan, O., Tonikian, R., Roberts, T., Sdicu, A.M., Shapiro, J., Sheikh, B., Suter, B., Wong, S.L., Zhang, L.V., Zhu, H., Burd, C.G., Munro, S., Sander, C., Rine, J., Greenblatt, J., Peter, M., Bretscher, A., Bell, G., Roth, F.P., Brown, G.W., Andrews, B., Bussey, H., Boone, C. (2004). Global mapping of the yeast genetic interaction network. Science 303, 808-813. [Supplementary Data]

Vink, E., Rodriguez-Suarez, R.J., Gerard-Vincent, M., Ribas, J.C., de Nobel, H., van den, E.H., Duran, A., Klis, F.M., Bussey, H. (2004). An in vitro assay for (1-6)-ß-D-glucan synthesis in Saccharomyces cerevisiae. Yeast 21, 1121-1131.

Wong, S.L., Zhang, L.V., Tong, A.H., Li, Z., Goldberg, D.S., King, O.D., Lesage, G., Vidal, M., Andrews, B., Bussey, H., Boone, C., Roth, F.P. (2004). Combining biological networks to predict genetic interactions. Proc. Natl. Acad. Sci.U.S.A 101, 15682-15687. [Supplementary data]

Green,R., Lesage,G., Sdicu,A.M., Menard,P., Bussey,H. (2003). A synthetic analysis of the Saccharomyces cerevisiae stress sensor Mid2p, and identification of a Mid2p interacting protein, Zeo1p, that modulates the PKC1-MPK1 cell integrity pathway. Microbiology 149, 2487-2499.

Pagé, N., Gerard-Vincent, M., Menard, P., Beaulieu, M., Azuma, M., Dijkgraaf, G.J., Li, H., Marcoux, J., Nguyen, T., Dowse, T., Sdicu, A.M., Bussey, H. (2003). A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin. Genetics 163, 875-894.

Dijkgraaf, G.J., Li, H., Bussey, H. (2002). Cell-Wall ß-Glucans of Saccharomyces Cerevisiae. In: Biopolymers, ed. A. SteinbuchelWeinheim ; Chichester: Wiley-VCH, 179-213.

Dijkgraaf, G.J., Abe, M., Ohya, Y., Bussey, H. (2002). Mutations in Fks1p affect the cell wall content of ß-1,3- and ß-1,6-glucan in Saccharomyces cerevisiae. Yeast 19, 671-690.

Giaever, G., Chu, A.M., Ni, L., Connelly, C., Riles, L., Veronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., Andre, B., Arkin, A.P., Astromoff, A., El Bakkoury, M., Bangham, R., Benito, R., Brachat, S., Campanaro, S., Curtiss, M., Davis, K., Deutschbauer, A., Entian, K.D., Flaherty, P., Foury, F., Garfinkel, D.J., Gerstein, M., Gotte, D., Guldener, U., Hegemann, J.H., Hempel, S., Herman, Z., Jaramillo, D.F., Kelly, D.E., Kelly, S.L., Kotter, P., LaBonte, D., Lamb, D.C., Lan, N., Liang, H., Liao, H., Liu, L., Luo, C., Lussier, M., Mao, R., Menard, P., Ooi, S.L., Revuelta, J.L., Roberts, C.J., Rose, M., Ross-Macdonald, P., Scherens, B., Schimmack, G., Shafer, B., Shoemaker, D.D., Sookhai-Mahadeo, S., Storms, R.K., Strathern, J.N., Valle, G., Voet, M., Volckaert, G., Wang, C.Y., Ward, T.R., Wilhelmy, J., Winzeler, E.A., Yang, Y., Yen, G., Youngman, E., Yu, K., Bussey, H., Boeke, J.D., Snyder, M., Philippsen, P., Davis, R.W., Johnston, M. (2002). Functional profiling of the Saccharomyces cerevisiae genome. Nature 418, 387-391.

Levinson, J.N., Shahinian, S., Sdicu, A.M., Tessier, D.C., Bussey, H. (2002). Functional, comparative and cell biological analysis of Saccharomyces cerevisiae Kre5p. Yeast 19, 1243-1259.

Li, H., Page, N., Bussey, H. (2002). Actin patch assembly proteins Las17p and Sla1p restrict cell wall growth to daughter cells and interact with cis-Golgi protein Kre6p. Yeast 19, 1097-1112.

Roopchand, D.E., Lee, J.M., Shahinian, S., Paquette, D., Bussey, H., Branton, P.E. (2001). Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A. Oncogene 20, 5279-5290.

Tong, A.H., Evangelista, M., Parsons, A.B., Xu, H., Bader, G.D., Page, N., Robinson, M., Raghibizadeh, S., Hogue, C.W., Bussey, H., Andrews, B., Tyers, M., Boone, C. (2001). Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294, 2364-2368.

Shahinian, S., Bussey, H. (2000). ß-1,6-Glucan synthesis in Saccharomyces cerevisiae. Mol.Microbiol. 35, 477-489.




(Updated: Aug 28, 2008)
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