The evolution of resistance to antibiotics is one of the most serious problems in developing effective medical therapies. We have shown that resistance to a novel class of antibiotics, antimicrobial peptides, readily evolves in the laboratory, despite claims that it would not.
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Perron, G.G., Zasloff, M. & Bell, G. 2005. Experimental evolution of resistance to an antimicrobial peptide. Proceedings of the Royal Society of London B 273: 251-256. (see News and Views, Nature 438: 170-171, 2005).
- Bell, G. & Gouyon P.-H. 2003. Arming the Enemy: the evolution of resistance to self-proteins. Microbiology 149:1367-1375.
We have also investigated the genetic structure of Salmonella populations that are capable of causing serious disease outbreaks in domestic animals.
- Perron, G., Quesny, S. & Bell, G. 2007. Genotypic diversity and antimicrobial resistance in asymptomatic Salmonella enterica serotype Typhimurium DT104. Infection, Genetics and Evolution 7: 223-228. NSERC DG.
- Perron, G.G., Bell,G. & Quessy, S. 2008. Parallel evolution of multidrug resistance in Salmonella enterica isolated from swine. FEMS Microbiology Letters (2008) 1-6.
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