|Dr. Laura NILSON|
Laura Nilson received a Ph.D. in Genetics from Yale University, where she studied the cellular mechanism of oncogenic transformation by bovine papillomavirus, a DNA tumor virus, in the laboratory of Daniel DiMaio. She then moved to the laboratory of Trudi Schüpbach, in the Department of Molecular Biology at Princeton University, as a National Cancer Institute postdoctoral fellow. While at Princeton Dr Nilson developed novel genetic strategies to study how the spatial information that establishes the dorsal-ventral axis of the Drosophila embryo is generated. Laura Nilson joined the Biology Department at McGill University in December 2000 as a Canada Research Chair in Developmental Genetics, and is a founding member of the DBRI.
Research in the Nilson laboratory
The research in Laura Nilson’s laboratory focuses on the mechanisms that generate asymmetry during development and ultimately produce a complex pattern of cell fate and function. This work utilizes the Drosophila ovary as a model system, where patterning along the dorsal-ventral axis of the somatic follicular epithelium is initiated by a single localized inductive signal from the underlying germline.
Rounding Atkey, M.R., Boisclair Lachance, J.-F., Walczak, M., Rebello, T. and Nilson, L.A. (2006) Capicua regulates follicle cell fate in the Drosophila ovary through repression of mirror. Development 133: 2115-2123.
Laplante, C. and Nilson, L.A. (2006) Differential expression of the adhesion molecule Echinoid drives epithelial morphogenesis in Drosophila. Development 133: 3255-3264.
Pai, L.-M., Wang, P.-Y., Chen, S.-R., Barcelo, G., Chang, W.-L., Nilson, L.A. and Schüpbach, T. (2006) The Drosophila cbl gene downregulates Egfr signaling by two distinct mechanisms. Mechanisms of Development 123: 450-462.
Caceres, L. and Nilson, L.A. (2005) Production of gurken in the nurse cells is sufficient for axial patterning in the Drosophila oocyte. Development 132: 2345-2353.
Goff, D.J., Nilson, L.A. and Morisato, D. (2001) Establishment of dorsal-ventral polarity of the Drosophila egg requires capicua action in ovarian follicle cells. Development 128: 4553-4562.
Nilson, L.A., and Schüpbach, T. (1999) EGF receptor signaling in Drosophila oogenesis. Current Topics in Development Biology 44: 203-244.
Nilson, L.A., and Schüpbach, T. (1998) Localized requirements for windbeutel and pipe reveal a dorsoventral prepattern within the follicular epithelium of the Drosophila ovary. Cell 93: 253-262.