[visit the Harrison Lab Website]

Paul Harrison received his Ph.D. in 1996 from the Imperial Cancer Research Fund and University College, London. His graduate studies centred on the analysis and modelling of protein structure, under the supervision of Dr. Michael Sternberg. Then, he moved to the University of California at San Francisco, to work as a postdoctoral fellow on the modelling and simulation of prion proteins and their folding problems, in collaboration with Professors Fred Cohen and Stanley Prusiner. Dr Harrison then transitioned to large-scale genome analysis as a research scientist in the laboratory of Mark Gerstein in the Department of Molecular Biophysics & Biochemistry, at Yale University. Paul Harrison has been an assistant professor in the Dept. of Biology at McGill University, since 2004.

Research in the Harrison laboratory

Dr Harrison’s laboratory focuses on a variety of topics and issues related to the large-scale analysis of genomes and proteomes, with a central goal of data-mining for insights into evolutionary processes.

Two current research projects are:

a detailed analysis of putative transcribed pseudogenes in the mammalian genomes (a transcribed pseudogene called makorin1-p1 has a developmental role in the mouse) and a complete exhaustive classification of compositionally-biased domains in eukaryotes.

Selected Publications

L. B. Harrison, Z. Yu, J. E Stajich, F. S Dietrich, & P.M. Harrison. (2007) Evolution of budding yeast prion-determinant sequences across diverse Fungi. J. Mol. Biol. 368: 273-282.

J. Karro, Y. Yan, D. Zheng, Z. Zhang, N. Carriero, P. Cayting, P.M. Harrison, & M. Gerstein. (2007) Pseudogene.org: a comprehensive database and comparison platform for pseudogene annotation. Nucleic Acids Res. 35: D55-D60.

P.M. Harrison. (2006) Exhaustive assignment of compositional bias reveals universally prevalent biased regions: analysis of functional associations in human and Drosophila. BMC Bioinformatics 7: 441-441.

Zhang Z., Carriero N., Zheng D., Karro J., Harrison P.M., Gerstein M. (2006)  PseudoPipe: an automated pseudogene identification pipeline. Bioinformatics 15: 1437-1439.

Juretic N., Hoen D. R., Huynh M. L., Harrison P. M. & Bureau T. E. (2005) The evolutionary fate of MULE-mediated duplications of host gene fragments in rice. Genome Res. 15: 1292-7.

P. M. Harrison et al. (2005) Transcribed processed pseudogenes in the human genome: an intermediate form of expressed retrosequence lacking protein-coding ability.  Nucleic Acids Res. 33(8): 2374-83.

P. M. Harrison and M. Gerstein. (2003) A method to assess compositionally biased regions in biological sequences and its application to glutamine/asparagine-rich domains in eukaryotic proteomes.  Genome Biol. 4(6): R40. [E-publication]

P. M. Harrison et al. (2002) A small reservoir of disabled ORFs in the Saccharomyces cerevisiae genome and its implications for the dynamics of proteome evolution.  J. Mol. Biol. 316: 409-419.

P. M. Harrison et al.  (2002) Molecular fossils in the human genome: Identification and analysis of the pseudogenes in chromosomes 21 and 22. Genome Res. 12: 272-280.

P. M. Harrison et al. (2001) Conformational propagation with prion-like characteristics in a simple model of protein folding. Protein Sci. 10: 819-835.

Abouheif] [Brouhard] [Dankort] [Dent] [Harrison] [Hekimi]
[Larsson] [Lasko] [Moon] [Nilson] [Roy] [Schöck] [Vogel] [Western] [Zetka]